Fig. 2.

SOX4 targets a subset of tRNA genes. (A) The top enriched DNA motifs identified through SOX4 ChIP-seq. The SOX4-binding motif represents 32.22% of all targets. (B) Genome-wide distribution of SOX4-binding sites. (C) The percentage of tRNA genes among all genes targeted by SOX4. (D) Representative ChIP-seq signal tracks surrounding SOX4-targeted tRNA genes. ChIP-seq was performed in biological triplicates (IP1, IP2, IP3). The input-DNA track was used as a control. (E) A genome-wide map of SOX4-targeted tRNA isodecoder genes indicated by pink and dark pink color.