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. 2020 Feb 29;21(5):1679. doi: 10.3390/ijms21051679

Figure 1.

Figure 1

(A) Butyrate suppresses the cytokine-induced expression of ICAM-1 in HSC-2 cells. HSC-2 were exposed for 24 h to 10 mM of acetate (C2), propionate (C3) and butyrate (C4), and then stimulated for three hours with 10 ng/mL of IL1β and TNFα. (+), indicates presence; (−), indicates absence. Data represent the mean change of ICAM-1 expression ± standard deviation. n = 3. Statistical analysis was based on ANOVA test with Tukey’s multiple comparisons correction and significant p-values are indicated. (B) Butyrate suppresses the cytokine-induced increase of ICAM-1 in a dose-dependent manner. HSC-2 cells were exposed to different concentrations of butyrate in the presence of IL1β and TNFα. Data represent the mean change of ICAM-1 expression ± standard deviation. n = 3 (C) Butyrate attenuates the IL1β- and TNFα-induced expression of ICAM-1. HSC-2 cells were exposed to 10 mM of butyrate (C4) in the presence or absence of 10 ng/mL IL1β and TNFα.