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. 2020 Mar 5;21(5):1795. doi: 10.3390/ijms21051795

Figure 3.

Figure 3

KMO activity was present in wild type (WT) but not in KMO knockout (KO) mice, and serum KP metabolites were altered in KMO KO mice. KMO activity was measured in livers isolated from WT and KMO KO mice (A). The KMO activity in WT liver isolate was blocked by a KMO inhibitor Ro61-8048, confirming that the observed activity was due KMO (n = 3). Retinal KP metabolites were higher in the KMO KO than in WT mice (B). WT and KMO KO mice (n = 6) were euthanized and KP metabolites were determined by LC-MS/MS. ns = not significant, * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.