Figure 6.

Examples of short-circuit current (SCC) data. Measurements in biopsies from an UC patient (A), and control (B). Biopsies mounted in the mini-Ussing-air-suction (MUAS) chambers were exposed to: amiloride (sodium absorption inhibitor, 20 µM), theophylline (non-specific phosphodiesterase inhibitor, 400 µM), a specific COX inhibitor (either COX-1, SC-560, or COX-2, rofecoxib, 500 nM) followed by indomethacin (non-specific COX inhibitor, 13 µM), prostaglandin E2 (PGE₂) in increasing concentrations (five-step, factor five from 5 to 3125 nM), and ultimately either bumetanide (Na⁺/K⁺/2Cl⁻-cotransporter inhibitor, 25 µM) or ouabain (Na⁺/K⁺-ATPase inhibitor, 200 µM).