Figure 7.

Mucosal function, expressed as a decrease in short-circuit current (SCC) after COX-2 enzyme inhibition with rofecoxib, correlated with endoscopy and histology for patient groups. Endoscopy (left): comparing functional data for controls (n = 11) to UC patients in clinical and endoscopic remission (n = 28). Histology (right): comparing functional data for UC patients with (n = 19) and without (n = 9) chronic inflammation. A larger decrease in SCC indicates elevated levels of PGE₂. Values are expressed as mean ± SEM. Asterisk indicates statistically significant difference between two groups (* p = 0.01).