Table 5.

SYRCLE’s tool for assessing risk of bias in the in vivo studies.

SYRCLE
Study	Selection Bias			Performance Bias		Detection Bias		Attrition Bias	Reporting Bias	Other
	Sequence Generation	Baseline Characteristics	Allocation Concealment	Random Housing	Blinding	Random Outcome Assessment	Blinding	Incomplete Outcome Data	Selective Outcome Reporting	Other Sources of Bias
PLT functions/features and growth factor in PLTs during osteoporosis
Xie et al. 2014 [40]	Yes	Yes	Yes	Yes	No	Unclear	No	No	Yes	No
Zhang et al. 2014 [41]	No	Yes	Unclear	Unclear	Unclear	Yes	No	No	Yes	No
Tang et al. 2017 [42]	No	Unclear	Unclear	Unclear	Unclear	Unclear	Unclear	No	Yes	Yes
PLT derivatives in osteoporosis
Lo et al. 2009 [49]	No	Unclear	No	Unclear	Unclear	No	No	No	Yes	No
Liu et al. 2011 [50]	No	No	No	No	No	No	No	No	Unclear	No
Clafshenkel et al. [51]	No	Yes	No	No	No	No	No	Unclear	Yes	Unclear
Chen et al. 2013 [52]	No	Unclear	No	No	Yes	No	Yes	No	Yes	No
Cho et al. 2014 [53]	No	No	No	No	No	No	Unclear	Yes	Yes	Yes
Jiang et al. 2016 [54]	No	Yes	No	No	No	No	No	No	Yes	Unclear
Wei et al. 2016 [55]	Unclear	Yes	Unclear	No	No	No	No	No	Yes	No
Rocha et al. 2017 [56]	No	No	No	No	No	No	No	Unclear	Yes	Yes
Sakata et al. 2018 [57]	No	Yes	Unclear	No	No	No	No	No	Yes	No
Engler-Pinto et al. 2019 [58]	Yes	Yes	Yes	No	No	No	Unclear	No	Yes	No

positive (good) indicator, unclear, negative (bad) indicator.