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. 2020 Feb 25;21(5):1558. doi: 10.3390/ijms21051558

Figure 2.

Figure 2

The morphology of skin (A) and a hypothetical model on the impact of β-caryophyllene on wound healing in mice (B). There are stem cell niches in the basal epidermis layer (shown as “Stem cells” in (A)) and in the upper bulge (shown as “Upper bulge (stem cells)” in (A)). Locations of human olfactory receptors OR2AT4, OR2AT4/7, OR51B5, and OR51E2 are indicated in red. The stem cells born at the basal epidermis layer differentiate into keratinocytes. The stem cells born at the upper bulge region of hair follicles differentiate into a new hair and do not participate in epidermal homeostasis [64]. When there is a cutaneous wound, the stem cells born at the upper bulge of hair follicles migrate to the basal epidermis stem cell region and convert to epidermal stem cells, and migrate to the wound bed (illustrated in (B)) [64]. BCP: β-caryophyllene.