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APP is localized in the Golgi apparatus and in the endolysosomal compartment. GT1 cells were grown on coverslips, fixed in PFA 4% and permeabilized in 0.1% TX-100 for 30 min, then they were stained with A8717 rabbit Ab (1:500) and Giantin (1:50) to label APP and Golgi, respectively. LysoTracker was used for 1 h in cell culture medium before fixation to label endolysosmes. Images are representative of at least 100 cells analysed. Scale bars, 10 μm.
