AAV |
Adeno-associated viral vector |
ATP |
Adenosine triphosphate |
BSG |
Basigin |
BSG1 |
Basigin-1 with three immunoglobulin domains |
BSG2 |
Basigin-2 with two immunoglobulin domains |
CBA |
Chicken beta-actin |
cGMP |
Cyclic guanosine monophosphate |
CMV |
Cytomegalovirus |
CNTF |
Ciliary neurotrophic factor |
COS-1 |
Immortalizing CV-1 cell line |
CsCl |
Cesium chloride |
CSNB |
Congenital stationary night blindness |
CX3CL1 |
C-X3-C motif chemokine ligand 1 or fractalkine |
DHAP |
Dihydroxyacetone phosphate |
EMA |
European Medicines Agency |
ERG |
Electroretinogram |
FDA |
Food and Drug Administration |
G3P |
Glycerol-3-phosphate |
G3PDH |
Glycerol-3-phosphate dehydrogenase |
G6P |
Glucose-6-phosphate |
GFP |
Green fluorescent protein |
GLP |
Good laboratory practices |
GLUT1 |
Glucose transporter SLC2A1 |
GMP |
Good manufacturing practice |
GNAT1 |
rod transducin alpha subunit |
HEK293 |
Human embryonic kidney 293 cell line |
HDAC4 |
Histone deacetylase 4 |
Ig |
Immunoglobulin domain |
ITRs |
Invert terminal repeats |
KLF15 |
Krüppel-like factor 15 |
LACT |
Lactate |
LCA |
Leber congenital amaurosis |
LCA2 |
Leber congenital amaurosis with a mutation in the RPE65 gene |
LCR |
Locus control region |
LDH |
Lactate dehydrogenase |
LRAT |
Lecithin-retinol acyltransferase |
MTCs |
Lactate transporters |
MPC |
Mitochondrial pyruvate carrier |
NADPH |
Nicotinamide adenine dinucleotide phosphate, reduced |
NHPs |
Non-human primates |
NXNL1 |
Nucleoredoxin-like 1gene |
OPN1L/MW |
Long and middle wave opsin gene |
OXPHO |
Oxidative phosphorylation |
PDE6B |
Phosphodiesterase 6B |
PPP |
Pentose phosphate pathway |
PRPF31 |
Pre-mRNA processing factor 31 |
PUFA |
Poly-unsaturated fatty acids |
PYR |
Pyruvate |
qPCR |
Quantitative polymerase chain reaction |
RB1 |
Tumor suppressor retinoblastoma 1 |
rd1
|
Retinal degeneration 1 mutant |
RdCVF |
Rod-derived cone viability factor |
RdCVFL |
Thioredoxin enzyme rod-derived cone viability factor long |
ROS |
Reactive oxygen species |
RP |
Retinitis pigmentosa |
RPE |
Retinal pigmented epithelium |
RPE65 |
Retinal pigment epithelium protein of 65 kDa |
SD-OCT |
Spectral domain optical coherence tomography |
SV40T |
Simian virus 40 large T antigen |
TCA |
Tricarboxylic acid cycle |
TXNRD |
Thioredoxin reductase |