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. 2020 Mar 10;21(5):1892. doi: 10.3390/ijms21051892

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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UBC metabolic network construction. (A) Hits (red) of the ¹H NMR metabolomic analysis inserted into Cytoscape and the related pathways assembled. Purine/pyrimidine metabolism seems to play a crucial role in UBC progression. (B) Hits of the purine/pyrimidine metabolism in grade III (T24) versus grade I (RT4) cell group comparison. Red: increased in grade III (T24), Yellow: decreased in grade III (T24). (C) Propylene glycol (or propane-1, 2-diol) has emerged as a novel, putative biomarker, with the EC 1.1.1.21 enzyme reaction for propylene glycol having been taken from KEGG.