Table 3.
First-quartile extracellular vesicle (EV)-miRNAs involved in osteoarthritis (OA) pathogenesis.
| Protective | ||||
|---|---|---|---|---|
| miRNA | % EV-genetic weight | Target | Tissue | Role |
| hsa-miR-24-3p | 19.0 | P16INK4A | Cartilage | Regulates senescence |
| hsa-miR-222-3p | 5.8 | HDAC4 | Cartilage | Prevents cartilage degradation |
| hsa-miR-193b-3p | 5.0 | TGFB2-3/MMP19 | Cartilage | Regulates inflammation |
| hsa-miR-92a-3p | 1.5 | ADAMTS4-5/HDAC2 | Cartilage | Anti-catabolic |
| hsa-miR-29a-3p | 1.1 | VEGF | Synovium | Inhibits synovial remodeling |
| hsa-miR-199a-3p | 0.9 | COX2 | Cartilage | Anti-catabolic |
| hsa-miR-27a-3p | 0.8 | FSTL1 | Synovium | Prevents synoviocyte migration |
| hsa-miR-26a-5p | 0.6 | iNOS | Cartilage | Cartilage homeostasis |
| hsa-miR-130a-3p | 0.6 | TNFa | Cartilage | Anti-inflammatory |
| hsa-miR-320a-3p | 0.5 | BMI1/RUNX2/MMP13 | Cartilage | Chondrogenic |
| hsa-miR-152-3p | 0.5 | DNMT | Synovium | Prevents synoviocyte migration |
| hsa-miR-17-5p | 0.5 | SQSTM1 | Cartilage | Induces Autophagy |
| hsa-miR-27b-3p | 0.3 | MMP13/LEPTIN | Cartilage | Anti-catabolic |
| hsa-miR-210-3p | 0.2 | DR6/HIF3a | Cartilage | Anti-apoptotic/promotes ECM |
| hsa-miR-30a-5p | 0.2 | ADAMTS5 | Cartilage | Cartilage homeostasis |
| hsa-miR-26b-5p | 0.1 | KPNA3 | Cartilage | Promotes NF-kB pathway |
| hsa-miR-149-5p | 0.1 | TNFa | Cartilage | Anti-inflammatory |
| Total | 37.9 | |||
| Destructive | ||||
| miRNA | % EV-genetic weight | Target | Tissue | Role |
| hsa-miR-21-5p | 4.7 | GDF5 | Cartilage | Chondrogenesis inhibitor |
| hsa-miR-30b-5p | 2.4 | BECN1/ATG5 | Cartilage | ECM degradation |
| hsa-miR-19b-3p | 1.4 | nd | Synovium | Induces NF-kB signaling |
| hsa-miR-34a-5p | 0.7 | SIRT1 | Cartilage | Apoptotic |
| hsa-miR-16-5p | 0.4 | SMAD3 | Cartilage | Cartilage degradation |
| hsa-miR-138-5p | 0.2 | FOXC1 | Cartilage | Promotes cartilage degradation |
| hsa-miR-483-5p | 0.1 | MATN3/TIMP2 | Cartilage | ECM degradation |
| Total | 9.8 | |||
| Protective/Destructive | ||||
| miRNA | % EV-genetic weight | Target | Tissue | Role |
| hsa-miR-125b-5p | 12.6 | ADAMTS4/ SYVN1 | Cartilage/Synovium | Prevents aggrecan loss/Pro-apoptotic |
| hsa-miR-221-3p | 4.7 | SDF1/ nd | Cartilage | Prevents ECM degradation/Pro-inflammatory |
| hsa-miR-145-5p | 1.7 | TNFRSF11B/ SOX9-SMAD3 | Cartilage | Chondrocyte proliferation/Cartilage degradation |
| hsa-miR-365-3p | 0.2 | HIF2a/ HDAC4 | Cartilage | Prevents ECM loss/Pro-inflammatory |
| Total | 19.2 | |||