Table 4.
Pathways associated with 40 candidate targets according to enrichment analysis based on KEGG.
| ID | Pathway | p-Value | p.adjust | Count | Gene IDs |
|---|---|---|---|---|---|
| hsa05034 | Alcoholism | 1.95 × 10−11 | 2.84 × 10−9 | 12 | MAOB/MAOA/HDAC5/CREB1/GRIN2D/GRIN1/HDAC2/HDAC9/GRIN2B/GRIN2A/CALM1/HDAC6 |
| hsa05031 | Amphetamine addiction | 6.17 × 10−10 | 4.51 × 10−8 | 8 | MAOB/MAOA/CREB1/GRIN2D/GRIN1/GRIN2/GRIN2A/CALM1 |
| hsa04015 | Rap1 signaling pathway | 4.29 × 10−6 | 8.94 × 10−5 | 8 | EGFR/GRIN1/PDGFRB/KIT/GRIN2B/GRIN2A/CSF1R/CALM1 |
| hsa04014 | Ras signaling pathway | 8.96 × 10−6 | 1.45 × 10−4 | 8 | EGFR/GRIN1/PDGFRB/KIT/GRIN2B/GRIN2A/CSF1R/CALM1 |
| hsa05030 | Cocaine addiction | 2.00 × 10−9 | 9.73 × 10−8 | 7 | MAOB/MAOA/CREB1/GRIN2D/GRIN1/GRIN2B/GRIN2A |
| hsa00982 | Drug metabolism - cytochrome P450 | 3.18 × 10−8 | 1.16 × 10−6 | 7 | MAOB/CYP2D6/MAOA/ALDH3A1/CYP2B6/CYP2C9/CYP2E1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.18 × 10−6 | 3.44 × 10−5 | 6 | CYP2D6/ALDH3A1/CYP2B6/CYP2C9/CYP2E1/HSD11B1 |
| hsa04713 | Circadian entrainment | 4.97 × 10−6 | 9.06 × 10−5 | 6 | CREB1/GRIN2D/GRIN1/GRIN2B/GRIN2A/CALM1 |
| hsa04720 | Long-term potentiation | 1.32 × 10−5 | 1.93 × 10−4 | 5 | GRIN2D/GRIN1/GRIN2B/GRIN2A/CALM1 |
| hsa00340 | Histidine metabolism | 3.36 × 10−6 | 8.18 × 10−5 | 4 | MAOB/MAOA/ALDH2/ALDH3A1 |