Figure 1.
Simplified scheme of L-arginine/NO pathway. Pathway players analyzed in the current study are written in black: metabolites in straight font and enzymes in italics. Inhibition is marked in red (as a dashed line if the effect is weak). PRMT, arginine N-methyltransferase; PM, plasma membrane; CATs, cationic amino acid transporters; DDAH, dimethylarginine dimethylaminohydrolase; DMA, dimethylamine; ADMA, asymmetric dimethylarginine; SDMA, symmetric dimethylarginine; NOS, nitric oxide synthase; NO, nitric oxide; ARG, arginase; ODC, ornithine decarboxylase; ASS, argininosuccinate synthase; ASL, argininosuccinate lyase; OTC, ornithine transcarbamylase; protein-CH3, methylated proteins.