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. 2020 Mar 6;21(5):1834. doi: 10.3390/ijms21051834

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DCs and their exosomes induced the proliferation of allogeneic T cell subpopulation. (A) After incubation with pulsed DCs, unpulsed DCs, and Exo/pulsed DCs, the percentage of both CD3⁺Vγ9 T cells and CD3⁺CD8⁺ T cells increased compared to T cells without such treatments. (B) Fold increase in the number of CD3⁺Vγ9 T cell and CD3⁺CD8⁺ T cell induced by DCs and their exosomes. Both pulsed DCs and their exosomes successfully induced CD3⁺Vγ9 T cell and CD3⁺CD8⁺ T cell proliferation, meanwhile the number of CD3⁺CD4⁺ T cells did not increase. Exo/pulsed DCs could induce the percentage of these cell sub populations similar to unpulsed DCs did, but exosomes isolated from unpulsed DCs did not. Data was presented as mean ± SD in quadruplicate cultures (* p < 0.05). DCs: dendritic cells; pulsed DCs: A549 tumor cell lysate-pulsed DCs; unpulsed DCs: A549 tumor cell lysate-unpulsed DCs; Exo/unpulsed DCs: exosomes isolated from unpulsed DCs; Exo/pulsed DCs: exosomes isolated from pulsed DCs.