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An illustration shows the effects of CDK5 in regulating DNA repair in neurons. Arrows indicate enhancing (upward direction) and reducing (downward direction) the protein’s functions respectively. CDK5 activity towards ATM in neurons is likely via p25. APE-1: AP (apurine/apirimidine) endonuclease 1; ATM: ataxia-telangiectasia mutated; BER: base excision repair; CDK5: cyclin-dependent kinase 5.
