8-OHdG	8-hydroxy-2’-deoxyguanosine
8-OHG	8-hydroxyguanine
AD	Alzheimer’s disease
Aβ	amyloid-β
AICD	APP intracellular domain
APE-1	AP (apurine/apirimidine) endonuclease 1
APP	amyloid precursor protein
APTX	ataxia with oculomotor apraxia
ATM	ataxia-telangiectasia mutated
AUC	area under the curve
BER	base excision repair
CDK	cyclin-dependent kinase
CIN	Chromosome instability
CNS	central nervous system
CSF	cerebrospinal fluid
DEGs	differentially expressed genes
DSBs	double strand breaks
FEN1	FLAP endonuclease 1
FXTAS	fragile-X-associated tremor/ataxia syndrome
HR	homologous recombination
HSV-1	herpes simplex virus-type 1
iPSC	induced pluripotent stem cells
LOAD	sporadic late onset AD
MCI	mild cognitive impairment
MUTYH	MYH glycosylase
NDP	adenine dinucleotide
NHEJ	non-homologous end joining
NEIL1	Nei like DNA glycosylase 1
NTH1	Nth like DNA glycosylase
OGG1	DNA glycosylase
PARP1	poly(ADP) ribose polymerase 1
PBMCs	peripheral blood mononuclear cells
PCAD	preclinical AD
PNKP	polynucleotide kinase phosphatase
POLβ	DNA polymerase β
POLD1	the catalytic subunit of DNA polymerase δ
PP4	Protein phosphatase 4
ROS	reactive oxygen species
SSBs	single strand breaks
TDP1	tyrosyl-DNA phosphodiesterase 1
TOP2β	topoisomerase Iiβ
WHO	World Health Organization
XRCC1	X-ray repair cross-complementing protein 1.