Table 2.

Alteration of BER genes in PBMCs of AD patients.

BER Genes	Changesi	AD Patients	Controls	Ref
OGG1	Reduction c.977C>G	n = 100 n = 105	n = 110 n = 130	[218,219] [216]
MUTYH	reduction	n = 100	n = 110	[219]
NEIL1	reduction	n = 100	n = 110	[219]
APE1	reduction	n = 100	n = 110	[219]
PARP1	Reduction rs1136410	n = 100 n = 120	n = 110 n = 110	[219] [212]
XCCR1	c.580C>T, c.1196A>G rs25487 (c.1196A>G)	n = 105 n = 120	n = 130 n = 110	[216] [212]
POLD1	reduction	n = 60	n = 40	[221]

i: AD vs control; AD: Alzheimer’s disease; APE-1: AP (apurine/apirimidine) endonuclease 1; OGG1: DNA glycosylase; MUTYH: MYH glycosylase; NEIL1: Nei like DNA glycosylase 1; PARP1: poly(ADP) ribose polymerase 1; POLD1: the catalytic subunit of DNA polymerase δ; XRCC1: X-ray repair cross-complementing protein 1.