Table 5.
Associations of IGF1 rs1520220 and IGF1R rs2229765 SNPs with melanoma risk in the GEM dataset.
| Logistic Regression Models | Crude (Model A) | Model B b | Model C c | Model D d | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNPs/Genetic Models | Genotypes | Cases n (%) | Controls n (%) | OR (95% CI) | p-Value a | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value |
| rs1520220/IGF1 Recessive | CC + CG | 139 (81.8%) |
127 (83.6%) |
Reference | -- | Reference | -- | Reference | -- | Reference | -- |
| GG | 26 (15.3%) |
8 (5.3%) |
2.97 (1.35, 7.23) |
0.010 | 2.86 (1.29, 6.98) |
0.014 | 2.79 (1.24, 6.92) |
0.018 | 2.80 (1.24, 6.93) |
0.018 | |
| Sex | -- | -- | -- | -- | 1.08 (0.68, 1.72) |
0.743 | -- | -- | 0.95 (0.58, 1.53) |
0.819 | |
| Family history | -- | -- | -- | -- | -- | -- | 6.60 (2.48, 22.86) |
0.0006 | 6.68 (2.50, 23.26) |
0.006 | |
| Model | -- | -- | -- | 0.006 | -- | 0.009 | -- | 0.0117 | -- | 0.0117 | |
| rs2229765/IGF1R Recessive | GG + GA | 157 (92.4%) |
122 (80.3%) |
Reference | -- | Reference | -- | Reference | -- | Reference | -- |
| AA | 9 (5.3%) |
24 (15.8%) |
0.29 (0.12, 0.62) |
0.003 | 0.29 (0.12, 0.63) |
0.003 | 0.25 (0.10, 0.57) |
0.002 | 0.25 (0.10, 0.56) |
0.002 | |
| Sex | -- | -- | -- | -- | 0.98 (0.62, 1.56) |
0.948 | -- | -- | 0.84 (0.52, 1.36) |
0.484 | |
| Family history | -- | -- | -- | -- | -- | -- | 8.38 (3.08, 29.79) |
0.00017 | 8.77 (3.19, 31.44) |
0.00014 | |
| Model | -- | -- | -- | 0.001 | -- | 0.001 | -- | 0.002 | -- | 0.002 | |
aP-value of the coefficient from the regression model. The overall model significance was derived from the likelihood ratio test (χ2 statistic). b Model B, adjusted for gender. c Model C, adjusted for family history of melanoma. d Model D, adjusted for gender and family history of melanoma.