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. 2020 Feb 25;21(5):1559. doi: 10.3390/ijms21051559

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regulation of lysosome trafficking by sphingolipids in podocytes. Dynein-mediated retrograde transport of lysosomes promotes their fusion with MVB. This transport is dependent on the TRPML1 channel-mediated Ca²⁺ release. In the lysosome, ASM converts SM into CER and AC converts CER to Sph. These sphingolipids, SM, Cer, and Sph had different effects on TRPML1 channel activity in podocytes, with inhibition by SM, no effect from Cer, but enhancement by Sph. SM, sphingomyelin; Cer; ceramide; Sph, sphingosine.