Table 2.
Clinical characteristics of chronic kidney disease patients in Taiwan.
| Variable | All CKD | Statin User | Non-Statin User | ||||
| (N = 67,001) | (N = 17,634) | (N = 49,367) | |||||
| No. | % | No. | % | No. | % | p Value | |
| Comorbidity | |||||||
| Hypertension | 42,456 | 63.37 | 15,067 | 85.44 | 27,386 | 55.48 | <0.0001 |
| Hyperlipidemia | 31,354 | 46.80 | 15,488 | 87.83 | 15,866 | 32.14 | <0.0001 |
| Atrial fibrillation | 6709 | 10.01 | 1933 | 10.96 | 4776 | 9.67 | <0.0001 |
| Heart failure | 14,293 | 21.33 | 4808 | 27.27 | 9485 | 19.21 | <0.0001 |
| Coronary artery disease | 27,044 | 40.36 | 10,018 | 56.81 | 17,026 | 34.49 | <0.0001 |
| Peripheral arterial disease | 8070 | 12.04 | 3406 | 19.31 | 4664 | 9.45 | <0.0001 |
| Diabetes disease | 29,584 | 44.15 | 12,261 | 67.53 | 17,323 | 35.09 | <0.0001 |
| Liver disease | 4650 | 6.94 | 806 | 4.57 | 3844 | 7.79 | <0.0001 |
| COPD | 15,477 | 23.10 | 4469 | 25.34 | 11,008 | 22.3 | <0.0001 |
| ARD | 2831 | 4.23 | 553 | 3.14 | 1828 | 3.70 | 0.0005 |
| Medical medicine† | |||||||
| Statin | <0.0001 | ||||||
| <28cDDDs | 49,367 | 73.68 | 0 | 0.00 | 49,367 | 100.00 | |
| 28-89cDDDs | 4239 | 6.33 | 4239 | 24.04 | 0 | 0.00 | |
| 90-180cDDDs | 3336 | 4.98 | 3336 | 18.92 | 0 | 0.00 | |
| >180cDDDs | 10,059 | 15.01 | 10,059 | 57.04 | 0 | 0.00 | |
| Statins type | |||||||
| Pravastatin | 2455 | 3.66 | 2455 | 13.92 | 0 | 0.00 | |
| Fluvastatin | 3438 | 5.13 | 3438 | 19.50 | 0 | 0.00 | |
| Atorvastatin | 9090 | 13.57 | 9090 | 51.55 | 0 | 0.00 | |
| Lovastatin | 2932 | 4.38 | 2932 | 16.63 | 0 | 0.00 | |
| Simvastatin | 5192 | 7.75 | 5192 | 29.44 | 0 | 0.00 | |
| Rosuvastatin | 5522 | 8.24 | 5522 | 31.31 | 0 | 0.00 | |
| Variable | All CKD | Statin User | Non-Statin User | ||||
| (N = 67,001) | (N = 17,634) | (N = 49,367) | |||||
| No. | % | No. | % | No. | % | p Value | |
| Medical medicine† | |||||||
| Aspirin | 22,873 | 34.14 | 9957 | 56.46 | 12916 | 26.16 | |
| NSAIDs | 41,357 | 61.73 | 13,131 | 74.46 | 28226 | 57.18 | |
| Antihypertensive drugs | |||||||
| ACEi | 21,536 | 32.14 | 8873 | 50.32 | 12663 | 25.65 | <0.0001 |
| ARB | 24,839 | 37.07 | 11,391 | 64.60 | 13448 | 27.24 | <0.0001 |
| Beta Blocker | 22,283 | 33.26 | 9608 | 54.49 | 12675 | 25.68 | <0.0001 |
| CCB | 33,544 | 50.06 | 12,638 | 71.67 | 20906 | 42.35 | <0.0001 |
| Diuretic | 29,650 | 44.25 | 10,624 | 60.25 | 19026 | 38.54 | <0.0001 |
| Anithyperglycemia drugs | |||||||
| Insulins | 14,324 | 21.38 | 5752 | 32.62 | 8572 | 17.36 | <0.0001 |
| Biguanides | 16,429 | 24.52 | 8364 | 47.43 | 8065 | 16.34 | <0.0001 |
| Sulfonylureas | 19,157 | 28.59 | 9148 | 51.88 | 10009 | 20.27 | <0.0001 |
| Thiazolidinedione | 6210 | 9.27 | 4037 | 22.89 | 2173 | 4.40 | <0.0001 |
| Antihyperlipidemic drugs | |||||||
| Nonstatin lipid-lowering drug | 1854 | 2.77 | 1389 | 7.88 | 465 | 0.94 | <0.0001 |
| Fibrate | 8373 | 12.50 | 5344 | 30.31 | 3029 | 6.14 | <0.0001 |
| Antihyperuric acid drugs | |||||||
| Benzbromarone | 1469 | 2.19 | 694 | 3.94 | 775 | 1.57 | <0.0001 |
| Probenecid | 7 | 0.01 | 3 | 0.02 | 4 | 0.01 | 0.3893 |
| Antihyperuric gout drugs | |||||||
| Allopurinol | 1235 | 1.84 | 598 | 3.39 | 637 | 1.29 | <0.0001 |
Abbreviations: CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; ARD, alcohol-related disease; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin Ⅱ receptor blocker; CCB, calcium channel blocker; NSAIDs, nonsteroidal anti-inflammatory drugs. cDDDs, cumulative defined daily doses.