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. 2020 Feb 26;21(5):1607. doi: 10.3390/ijms21051607

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Altered mRNA levels of genes expressing enzymes of ceramide metabolism in ASAH1^KD cells. The graph represents the mRNA levels of CERK (Cer kinase), SMPD1 and SMPD2 (acid and neutral sphingomyelinase), SGMS1 (SM synthase 1), DEGS1 (delta 4-desaturase, sphingolipid 1), GBA (glucosylceramidase beta), ASAH2 (neutral ceramidase), ACER2 and ACER3 (alkaline ceramidases 2 and 3) and ceramide synthases (CERS1, CERS2, CERS5, and CERS6) sphingolipid genes in ASAH1^KD cells relative to shScramble cells after normalization with the endogenous GAPDH gene. Values represent the mean ± SEM of three independent triplicate experiments. Asterisks indicate statistically significant (* p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 significant, two-way ANOVA analysis).