Process of molar tooth development in mouse. (a–e) Tooth development begins with thickening of the oral epithelium (E) and progresses to crown (bud, cap, and bell stages) and root formation stages. Calcification of enamel, dentin (D), and cementum occurs after the bell stage. The formation stages “initiation,” “crown formation,” and “root formation” correspond to the terms in Table 1. Higher magnification of the boxed region in “d” is shown in “e.” AB, ameloblast; DM, dental mesenchyme; DP, dental papillae; ED, embryonic day; EO, enamel organ; HERS, Hertwig’s epithelial root sheath; ODB, odontoblast; P, pulp; PD, postnatal day. Scale bars = 100 μm (a), 50 μm (b–d,f), 25 μm (e).