Table 1.
Stage | Expressing Cells | Function | References | |
---|---|---|---|---|
Shh | Ptch, Smo, Gli | |||
Initiation | Epithelium | Dental mesenchyme | Epithelial invagination | [32,33,34] |
Crown formation | Enamel organ | Enamel organ | Ameloblast differentiation | [35,36,37,38] |
Calcification | Enamel organ | Dental papillae | Tooth morphogenesis | [37,38,39,40,41] |
Root formation | HERS | Dental mesenchyme | Root elongation | [35,42,43,44] |