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. 2020 Feb 26;21(5):1587. doi: 10.3390/ijms21051587

Table 1.

Roles of Shh signaling during tooth development.

Stage Expressing Cells Function References
Shh Ptch, Smo, Gli
Initiation Epithelium Dental mesenchyme Epithelial invagination [32,33,34]
Crown formation Enamel organ Enamel organ Ameloblast differentiation [35,36,37,38]
Calcification Enamel organ Dental papillae Tooth morphogenesis [37,38,39,40,41]
Root formation HERS Dental mesenchyme Root elongation [35,42,43,44]