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. 2020 Mar 4;21(5):1750. doi: 10.3390/ijms21051750

Figure 2.

Figure 2

Angiogenesis process—In endometriosis, the central role in pathophysiological mechanisms is attributed to macrophages. These cells increase the intranuclear expression of vascular endothelial growth factor (VEGF) and cyclooxigenase 2 (COX-2) genes, leading to increased angiogenesis and an inflammatory environment [58].