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Relationship of Lamin B2 with Lamin A at early AD stages. Lamin B2 immunopositivity (DAB-brown) covers the nucleoplasm of neurons with nucleoli displaced to the periphery or without nucleoli and signs of degeneration (A,D). A reinforced Lamin B2 associated with Lamin A (red- amino-ethyl-carbazole) characterizes neurons with euchromatic nuclei with prominent nucleoli (B,C). In the hippocampus at AD I-II stages the two neuron populations coexist in CA1 (E) and CA3 (F), scale bar—5 µm.
