Figure 8.

Nuclear dynamics of Tau, nuclear lamins, and H4K20me3 in the hippocampus of adult, senile AD I-II, AD III-IV, and AD V-VI Braak stages. Adult neurons have low phosphorylated Tau-AT100 expression and Lamin B1 and Lamin B2 are the components of NL. Senile neuron increment their content of phosphorylated Tau-AT100 and AT8. Changes in Lamin B2 determine the two types of neurons, those with reinforced perinuclear Lamin B2 (left) and those with nucleoplasmic Lamin B2 (right). Lamin A (left) expression is associated with H4K20me3 repressive marks in LADs and NADs. The increased presence of cytoplasmic Tau leads to hyperphosphorylation, oligomer and NFT formation.