Figure 1.

Curcumin ameliorate proteinuria, Blood Urea Nitrogen (BUN) levels and renal pathology in the anti-glomerular basement membrane (GBM) mouse model. Upon treatment with curcumin, anti-GBM subjected mice (model for acute immune nephritis) demonstrated reduced 24-h proteinuria (A), BUN (B), serum creatinine (C), GN score (D), crescent formation (E), tubules and interstitial pathology (F) and lymphocytic infiltration (G), compared to the placebo group. H&E staining of kidney is also shown in (H). Shown are representative photomicrographs of Periodic acid–Schiff (PAS) stained kidney sections isolated from curcumin-treated and placebo treated mice. All images were taken at 200× total magnification. Data were compared using a two tailed Student’s t-test. * represents p < 0.05, ** represents p < 0.01.