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Curcumin ameliorates splenomegaly and lymphocyte numbers and activation in the MRL.lpr spontaneous lupus mouse model. Curcumin treatment significantly reduced splenomegaly (A) and splenocyte number (B) in MRL.lpr mice compared to placebo mice. B cell (C,D), T cell (E–H), macrophage (I,J) and dendritic cell (K,L) populations and their activation status were also impacted by curcumin treatment. * indicates p value < 0.05, ** indicates p value < 0.01 as compared to the placebo group.
