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Schematic of gut–brain axis changes in Tg2576 mouse model of AD. Gut precedes in Aβ pathology compared to brain identified using Tg2576 AD mouse model. Reduced mucus fucosylation, reduced e-cadherin and increased IL-9, VEGF-α, and IP-10 associated with Aβ depositions in the gut. Aβ depositions was co-localized with blood vessels before central pathology in Tg 2576 AD mouse model.
