Table 5.
Crucial GO category in the microRNA-GO network (degree >20)
| GO ID | GO (name) | Degree | P value | |
|---|---|---|---|---|
| BP | GO:0034641 | cellular nitrogen compound metabolic process | 32 | 1.93E-70 |
| BP | GO:0009058 | biosynthetic process | 32 | 8.87E-43 |
| BP | GO:0008150 | biological_process | 32 | 2.79E-06 |
| BP | GO:0009056 | catabolic process | 31 | 2.45E-18 |
| BP | GO:0022607 | cellular component assembly | 31 | 4.15E-17 |
| BP | GO:0006351 | transcription, DNA-templated | 31 | 0.0449519 |
| BP | GO:0006464 | cellular protein modification process | 30 | 5.95E-38 |
| BP | GO:0044281 | small molecule metabolic process | 30 | 2.21E-23 |
| BP | GO:0006950 | response to stress | 30 | 3.49E-09 |
| BP | GO:0034655 | nucleobase-containing compound catabolic process | 29 | 1.98E-11 |
| BP | GO:0065003 | macromolecular complex assembly | 29 | 1.19E-10 |
| BP | GO:0006461 | protein complex assembly | 29 | 3.48E-07 |
| BP | GO:0016192 | vesicle-mediated transport | 29 | 0.0433165 |
| BP | GO:0002376 | immune system process | 28 | 2.04E-06 |
| BP | GO:0008219 | cell death | 28 | 2.97E-06 |
| BP | GO:0006259 | DNA metabolic process | 28 | 0.0073611 |
| BP | GO:0010467 | gene expression | 27 | 3.60E-35 |
| BP | GO:0044403 | symbiosis, encompassing mutualism through parasitism | 27 | 1.57E-26 |
| BP | GO:0044267 | cellular protein metabolic process | 27 | 8.96E-20 |
| BP | GO:0048011 | neurotrophin TRK receptor signaling pathway | 26 | 6.94E-37 |
| BP | GO:0016032 | viral process | 26 | 2.41E-26 |
| BP | GO:0043687 | post-translational protein modification | 26 | 4.23E-17 |
| BP | GO:0061024 | membrane organization | 26 | 5.18E-12 |
| BP | GO:0007267 | cell-cell signaling | 26 | 1.13E-09 |
| BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 26 | 1.07E-05 |
| BP | GO:0006367 | transcription initiation from RNA polymerase II promoter | 26 | 5.57E-05 |
| BP | GO:0042592 | homeostatic process | 26 | 0.0079643 |
| BP | GO:0030198 | extracellular matrix organization | 26 | 0.0361203 |
| BP | GO:0007596 | blood coagulation | 25 | 6.77E-18 |
| BP | GO:0007268 | synaptic transmission | 25 | 5.55E-14 |
| BP | GO:0016070 | RNA metabolic process | 25 | 3.88E-06 |
| BP | GO:0045087 | innate immune response | 25 | 0.0002734 |
| BP | GO:0048870 | cell motility | 25 | 0.000421 |
| BP | GO:0007010 | cytoskeleton organization | 25 | 0.0095913 |
| BP | GO:0016071 | mRNA metabolic process | 24 | 3.49E-09 |
| BP | GO:0007411 | axon guidance | 24 | 0.0001162 |
| BP | GO:0097190 | apoptotic signaling pathway | 24 | 0.0084989 |
| BP | GO:0007399 | nervous system development | 24 | 0.0092641 |
| BP | GO:0006790 | sulfur compound metabolic process | 24 | 0.0392062 |
| BP | GO:0038095 | Fc-epsilon receptor signaling pathway | 23 | 1.46E-26 |
| BP | GO:0007173 | epidermal growth factor receptor signaling pathway | 23 | 1.72E-14 |
| BP | GO:0030203 | glycosaminoglycan metabolic process | 23 | 2.21E-10 |
| BP | GO:0000278 | mitotic cell cycle | 23 | 2.73E-08 |
| BP | GO:0030168 | platelet activation | 23 | 3.73E-07 |
| BP | GO:0008286 | insulin receptor signaling pathway | 23 | 2.61E-06 |
| BP | GO:0019221 | cytokine-mediated signaling pathway | 23 | 0.0327518 |
| BP | GO:0008543 | fibroblast growth factor receptor signaling pathway | 22 | 3.49E-09 |
| BP | GO:0034142 | toll-like receptor 4 signaling pathway | 22 | 2.23E-08 |
| BP | GO:0034330 | cell junction organization | 22 | 3.30E-06 |
| BP | GO:0006325 | chromatin organization | 22 | 0.0046663 |
| BP | GO:0022617 | extracellular matrix disassembly | 22 | 0.0138599 |
| BP | GO:0006091 | generation of precursor metabolites and energy | 22 | 0.0460089 |
| BP | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 21 | 1.01E-13 |
| BP | GO:0034162 | toll-like receptor 9 signaling pathway | 21 | 1.01E-09 |
| BP | GO:0002224 | toll-like receptor signaling pathway | 21 | 6.22E-07 |
| BP | GO:0048015 | phosphatidylinositol-mediated signaling | 21 | 1.05E-06 |
| BP | GO:0006928 | cellular component movement | 21 | 9.77E-05 |
| BP | GO:0006644 | phospholipid metabolic process | 21 | 0.0001544 |
| BP | GO:0000086 | G2/M transition of mitotic cell cycle | 21 | 0.0024742 |
| CC | GO:0005575 | cellular_component | 32 | 1.93E-22 |
| CC | GO:0043234 | protein complex | 30 | 5.11E-20 |
| CC | GO:0005829 | cytosol | 30 | 1.17E-15 |
| CC | GO:0005654 | nucleoplasm | 30 | 1.03E-13 |
| CC | GO:0005815 | microtubule organizing center | 26 | 0.0031329 |
| MF | GO:0043167 | ion binding | 32 | 5.38E-85 |
| MF | GO:0003674 | molecular_function | 32 | 9.58E-29 |
| MF | GO:0001071 | nucleic acid binding transcription factor activity | 30 | 1.33E-22 |
| MF | GO:0000988 | protein binding transcription factor activity | 27 | 3.47E-21 |
| MF | GO:0019899 | enzyme binding | 27 | 1.21E-20 |
| MF | GO:0008092 | cytoskeletal protein binding | 28 | 1.25E-16 |
| MF | GO:0030234 | enzyme regulator activity | 29 | 2.03E-10 |
| MF | GO:0022857 | transmembrane transporter activity | 28 | 9.52E-05 |
| MF | GO:0030674 | protein binding, bridging | 23 | 0.0343038 |