Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 17;16(8):1303–1323. doi: 10.7150/ijbs.38962

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Effects of reintroduction or inhibition of ALDH2 on the cellular viability of PC12 cells exposed to OGD injury. A and B. OGD injury reduced ALDH2 protein levels as shown in the Western blot image. GAPDH was used as a loading control. Quantitative data of ALDH2 levels are shown. C and D. Overexpression of ALDH2 was achieved by plasmid transfection and verified by Western blot. E and F. ALDH2 siRNA reduces ALDH2 levels in the primary cortical neurons and PC12 cell lines. G -J. The effect of overexpression or knockdown of ALDH2 on cell survival and LDH leakage of the primary cortical neurons and PC12 cells under OGD conditions. K and LALDH2 overexpression or inhibition alleviated or aggravated mitochondria-derived ROS production. M-P. The level of MDA and 4-HNE in the primary cortical neurons and PC12 cells detected by ELISA kits.

Effects of reintroduction or inhibition of ALDH2 on the cellular viability of PC12 cells exposed to OGD injury. A and B. OGD injury reduced ALDH2 protein levels as shown in the Western blot image. GAPDH was used as a loading control. Quantitative data of ALDH2 levels are shown. C and D. Overexpression of ALDH2 was achieved by plasmid transfection and verified by Western blot. E and F. ALDH2 siRNA reduces ALDH2 levels in the primary cortical neurons and PC12 cell lines. G -J. The effect of overexpression or knockdown of ALDH2 on cell survival and LDH leakage of the primary cortical neurons and PC12 cells under OGD conditions. K and LALDH2 overexpression or inhibition alleviated or aggravated mitochondria-derived ROS production. M-P. The level of MDA and 4-HNE in the primary cortical neurons and PC12 cells detected by ELISA kits.