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. 2020 Feb 17;16(8):1303–1323. doi: 10.7150/ijbs.38962

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ALDH2 conferred neuroprotection via suppressing JNK-mediated caspase-3 activation. A and B. The effect of overexpression or knockdown of ALDH2 on phosphorylated JNK (p-JNK) in PC12 cells exposed to OGD damage. C and D. JNK specific inhibitor SP600125 (SP) promoted cell survival from ALDH2 deprivation under OGD conditions. E. SP significantly relieved caspase-3 activity measured by the ELISA kit. F and G. Western blots were used to analyze the effect of SP on activated caspase-3. H and I. JNK specific activator Anisomycin (Ani) increased cell death from ALDH2 reintroduction under OGD conditions. J. Ani significantly increased caspase-3 activity measured by ELISA kit. K and L. Selected graphs of active caspase-3 affected by Ani. Mean ± SD was used to describe the data. ^# indicated P < 0.05.

ALDH2 conferred neuroprotection via suppressing JNK-mediated caspase-3 activation. A and B. The effect of overexpression or knockdown of ALDH2 on phosphorylated JNK (p-JNK) in PC12 cells exposed to OGD damage. C and D. JNK specific inhibitor SP600125 (SP) promoted cell survival from ALDH2 deprivation under OGD conditions. E. SP significantly relieved caspase-3 activity measured by the ELISA kit. F and G. Western blots were used to analyze the effect of SP on activated caspase-3. H and I. JNK specific activator Anisomycin (Ani) increased cell death from ALDH2 reintroduction under OGD conditions. J. Ani significantly increased caspase-3 activity measured by ELISA kit. K and L. Selected graphs of active caspase-3 affected by Ani. Mean ± SD was used to describe the data. ^# indicated P < 0.05.