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. 2020 Mar 14;26:e920394-1–e920394-12. doi: 10.12659/MSM.920394

Figure 1.

Figure 1

Inhibition of microRNA-143 (miR-143) reduced doxorubicin-induced cardiac toxicity in mice. (A) The expression of miR-143 in mouse hearts and H9C2 cells (n=6). (B) Statistical findings of the efficacy of the miR-143 antagomir (n=6). (C–E) Fractional shortening (FS), +dP/dt, and stroke volume in the mouse groups (n=8). (F, G) Bodyweight and heart weight in the mouse groups (n=6). (H–J) Serum concentrations of cardiac troponin T (cTnT), lactate dehydrogenase (LDH), and creatine kinase myocardial band (CK-MB) isoenzyme in the mouse groups (n=6). (K) Survival data in mice with or without miR-143 antagomir treatment (n=20). Data are presented as the mean±standard deviation (SD) with the 95% confidence interval (CI). * P<0.05 versus the normal saline (NS)+antagomir control group. # P<0.05 versus the doxorubicin+antagomir control group. In Figure A and B, * P<0.05 versus the matched group.