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. 2020 Mar 14;26:e920394-1–e920394-12. doi: 10.12659/MSM.920394

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© Med Sci Monit, 2020

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AKT inhibition reversed the effect of microRNA-143 (miR-143) on doxorubicin-induced cardiac toxicity in vivo. (A) Quantitative result of caspase-3 activity in murine hearts (n=6). (B) Malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) production in the myocardium (n=6). (C) Cardiac fractional shortening (FS) and stroke volume in murine hearts (n=8). (D) Serum cardiac troponin T (cTnT) and lactate dehydrogenase (LDH) levels in mice in the study groups (n=6). (E) MDA and 4-HNE levels in murine hearts (n=6). (F) Data on caspase-3 activity in the myocardium (n=6). (G) FS and stroke volume in mice among groups (n=8). (H) Serum level of cTnT in mice (n=6). Data are presented as the mean±standard deviation (SD) with the 95% confidence interval (CI). * P<0.05 versus the matched group.