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. 2020 Jan 8;69(4):749–759. doi: 10.2337/db19-0432

Figure 1.

Figure 1

SC-Exos improve neurological function in db/db mice. SC-Exos characterized by TEM (A), NanoSight (B), and Western blot analysis (C). Treatment of diabetic mice with SC-Exos (db/db+SC-Exo, black, n = 10 mice/group), but no FC-Exos (db/db+FC-Exo, blue, n= 8 mice/group) and liposome (db/db+liposome, purple, n = 8 mice/group), improves neurological function measured by MCV (D), SCV (E), plantar test (F), and von Frey test (G), respectively. Scale bar = 100 nm. *P < 0.05, **P < 0.01 vs. the nondiabetic mice treated with saline (db/m+saline, red, n = 10 mice/group); #P < 0.05, ##P < 0.01 vs. the diabetic mice treated with saline (db/db+saline, green, n = 10 mice/group).