Figure 7.

Evaluation of idelalisib toxicity to mouse eyes. Idelalisib was intravitreally injected into the mouse eyes on P12 to achieve a final vitreal concentration of ∼10 μmol/L. This day was considered day 0. A–D: On day 30, the mouse eyes were examined by ERG (dark adaption), OCT, FFA, and histological analysis. Representative data are presented in each panel for the indicated analysis. Scale bar = 200 μm. H & E, hematoxylin and eosin; INL, inner nuclear layer; L, left eye; ONL, outer nuclear layer; R, right eye.