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. 2020 Feb 24;17(6):693–701. doi: 10.7150/ijms.42654

Figure 2.

Figure 2

Differential changes of CREBZF and miRNA expression in gastrointestinal biopsy tissues from low/high-grade dysplasia and early gastric cancer (EGC) patients. (A) Representative immunohistochemistry stains of CREBZF between sample-matched normal (upper panels) and adenoma/dysplasia (down panels) of gastrointestinal biopsy tissues. Scale bar = 100 μm. (B) In situ hybridization of miRNAs (hsa-miR-421 and hsa-miR-29b-1-5p). In situ hybridization analyses using DIG-labeled miRCURY LNA microRNA detection probe complementary to hsa-miR-421 and hsa-miR-29b-1-5p were performed on paraffin sections of the gastrointestinal biopsy tissues. Scale bar = 200 μm. LGD, low-grade dysplasia; HGD, high-grade dysplasia; EGC, early gastric cancer.