Table 1.

Demographic characteristics of clinically assessed subjects with/without diabetes categorized by APOE carrier status in the NACC database

Clinically assessed cohorts	Total	Normal	Diabetes	P‐value
No.	24,967	21,185	3782	–
Sex (M:F)	10,896:14,071	9110:12,075	1286:1996	<0.0001
Age at initial visit (years)	74.3 ± 8.1	74.3 ± 8.2	74.1 ± 7.5	0.0734
Age at last visit (years)	77.9 ± 8.5	77.9 ± 8.6	77.7 ± 8.0	0.0872
Education (years)	15.1 ± 3.4	15.3 ± 3.3	14.2 ± 3.8	<0.0001
White:Black:other	20,805:3185:977	18,242:2250:693	2563:935:284	<0.0001
Demented:non‐demented	11,094:13,873	9525:11,660	1569:2213	<0.0001
By APOE carrier status
ε2/ε2 or ε2/ε3 (APOE2)
No.	2390	1974	416	–
Sex (M:F)	1010:1380	824:1150	186:230	0.2661
Age at initial visit (years)	74.9 ± 8.6	74.9 ± 8.8	74.6 ± 7.9	0.4816
Age at last visit (years)	78.9 ± 9.2	79.0 ± 9.4	78.4 ± 8.3	0.1866
Education (years)	15.3 ± 3.3	15.4 ± 3.1	14.4 ± 3.6	<0.0001
White:Black:other	1891:412:87	1635:276:63	256:136:24	<0.0001
Demented:non‐demented	693:1697	572:1402	121:295	0.9642
ε3/ε3 (APOE3)
No.	12,415	10,440	1975	–
Sex (M:F)	5406:7009	4473:5967	933:1042	0.0003
Age at initial visit (years)	74.8 ± 8.3	74.9 ± 8.4	74.3 ± 7.7	0.0031
Age at last visit (years)	78.5 ± 8.8	78.6 ± 8.9	78.0 ± 8.2	0.0031
Education (years)	15.1 ± 3.5	15.3 ± 3.4	14.1 ± 4.0	<0.0001
White:Black:other	10,488:1337:590	9113:923:404	1375:414:186	<0.0001
Demented:non‐demented	4574:7841	3871:6569	703:1272	0.2092
ε3/ε4 or ε4/ε4 (APOE4)
No.	9490	8212	1278	–
Sex (M:F)	4209:5281	3594:4618	615:663	0.0036
Age at initial visit (years)	73.5 ± 7.5	73.5 ± 7.6	73.7 ± 7.0	0.525
Age at last visit (years)	76.9 ± 7.9	76.8 ± 8.0	77.0 ± 7.5	0.4768
Education (years)	15.1 ± 3.4	15.2 ± 3.3	14.3 ± 3.7	<0.0001
White:Black:other	7916:1284:290	7038:956:218	878:328:72	<0.0001
Demented:non‐demented	5530:3960	4826:3386	704:574	0.0133

For continuous data, values are the mean ± SD.

P‐values are from one‐way ANOVA (continuous data) or chi‐square test (categorical value). M = male, F = female.