Figure 2.

Molecular signature of Alzheimer's disease (AD). Upper‐left triangle: Linkage disequilibrium (LD) pattern (r, %) in the pooled sample from all studies, non‐cases, for 32 single nucleotide polymorphisms (SNPs). Lower‐right triangle: Heat map for Δr = r_cases−r_non‐cases representing the molecular signature of AD. Red denotes r_cases > r_non‐cases and blue denotes r_cases < r_non‐cases. Purple and yellow show the estimates with opposite signs of r_cases and r_non‐cases. For convenience, positive sign of r_non‐cases has been selected. Legend on the right shows color‐coded P‐values. The heat map shows that LD changes for the vast majority of SNPs in the entire region spanning all five genes. Numerical estimates are shown in Table S2