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. 2020 Feb 6;12(1):e12008. doi: 10.1002/dad2.12008

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© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Significant ε2‐ and ε4‐related molecular signatures of Alzheimer's disease (AD). (A) The ε2‐related signature is characterized by a significant decrease (blue) in linkage disequilibrium (LD) for rs7412 with eight single nucleotide polymorphisms (SNPs) in AD cases compared with non‐cases. (B) The ε4‐related signature is characterized by a significant increase (red) for LD of rs429358 with 13 SNPs, including rs7412, in AD cases compared with non‐cases. Insets show examples of small LD between SNPs indicated by brackets. Vertical lines show 95% confidence intervals. Numerical estimates are shown in Table S2