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. Author manuscript; available in PMC: 2020 Mar 21.
Published in final edited form as: Neuron. 2019 May 7;102(6):1143–1156.e4. doi: 10.1016/j.neuron.2019.04.008

Figure 1. Spinal Axonal Trajectories of Muscle-Specific Proprioceptors in Wild-Type Mice.

Figure 1.

(A-C) Representative spinal axonal projections from proprioceptive sensory neurons innervating distinct hindlimb muscles.

(D-F) Reconstruction of (D) GL(m), GL(l), (E) GS, and

(F) IF sensory axon trajectories.

(G) Overlay of axonal trajectories.

(H) Average sensory axon emergence points from the DF and axon trajectories from the DF to the region of convergence (RoC, red dotted lines). Emergence points (ML axis from the midline of the spinal cord, and DV axis of the DF): square, IF, (47 ± 2 μm, 218 ± 10 μm); dark-blue triangle, GL(m), (52 ± 3 μm, 299 ± 13 μm); diamond, GS, (56 ± 8 μm, 327 ± 24 μm); yellow triangle, GL(l), (254 ±19 μm, 388 ±10 μm).

(I) Sensory axon trajectory angles from the RoC to the ventral spinal cord relative to the ML axis (GL(m+l): 22° ± 2°, GS: 35° ± 2°, IF: 57° ± 1°). Dotted line depicts gray matter boundary. SEM of trajectories in (H) and (I) is shown as shaded colors. See Table S2 for experimental sample sizes.