Table 1.
ProTox-II toxicity prediction of cemtirestat.
| No | Target | Prediction | Probability |
|---|---|---|---|
| 1 | Hepatotoxicity | Active | 0.52 |
| 2 | Carcinogenicity | Inactive | 0.52 |
| 3 | Immunotoxicity | Inactive | 0.99 |
| 4 | Mutagenicity | Inactive | 0.61 |
| 5 | Cytotoxicity | Inactive | 0.66 |
| 6 | Aryl hydrocarbon Receptor (AhR) | Inactive | 0.62 |
| 7 | Androgen Receptor (AR) | Inactive | 0.99 |
| 8 | Androgen Receptor Ligand Binding Domain (AR-LBD) | Inactive | 0.97 |
| 9 | Aromatase | Inactive | 0.82 |
| 10 | Estrogen Receptor Alpha (ER) | Inactive | 0.86 |
| 11 | Estrogen Receptor Ligand Binding Domain (ER-LBD) | Inactive | 0.98 |
| 12 | Peroxisome Proliferator Activated Receptor Gamma (PPAR-Gamma) | Inactive | 0.84 |
| 13 | Nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (nrf2/ARE) | Inactive | 0.91 |
| 14 | Heat shock factor response element (HSE) | Inactive | 0.91 |
| 15 | Mitochondrial Membrane Potential (MMP) | Inactive | 0.81 |
| 16 | Phosphoprotein (Tumor Supressor) p53 | Inactive | 0.83 |
| 17 | ATPase family AAA domain-containing protein 5 (ATAD5) | Inactive | 0.94 |