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. 2020 Mar 17;13:2299–2309. doi: 10.2147/OTT.S237751

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© 2020 Yang et al.

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ANGPTL4 increases cell proliferation of thyroid tumor. (A) ANGPTL4 was significantly increased in the group with the maximum diameter greater than 2.5 cm. (B) The gene signatures of cell proliferation (GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION) were enriched with subgroup of ANGPTL4-Higher expression. False discovery rate (FDR) gives the estimated probability that a gene set with a given normalized ES (NES) represents a false-positive finding; FDR < 0.25 is an accepted cutoff for the identification of biologically significant gene sets. (C) ANGPTL4 protein level was positively correlated with the tumor size. (D) ANGPTL4 overexpression enhanced cell proliferation of TPC-1 cells by CCK-8 assays. Overexpression of ANGPTL4 in TPC-1 cells was verified by Western blot analysis; GAPDH was used as a loading control. (E) ANGPTL4 knockdown significantly inhibited cell viability of TPC-1 cells. Cells were cultured in 96-well plates and stained with CCK8 at 72 h. (F) ANGPTL4 overexpression enhanced cell proliferation of BCPAP cells. Overexpression of ANGPTL4 in BCPAP cells was verified by Western blot analysis; GAPDH was used as a loading control. (G) ANGPTL4 knockdown significantly inhibited cell viability of BCPAP cells.