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. 2020 Mar 17;13:2299–2309. doi: 10.2147/OTT.S237751

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© 2020 Yang et al.

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ANGPTL4 promoted AKT signaling activation and AKT-mediated proliferation in thyroid cancer. (A) Gene signatures of AKT signaling were enriched in thyroid cancer (n=4) in comparison with normal thyroid tissues (n=6) by GSEA plots. (B) pAKT protein levels in thyroid cancer and its adjacent tissue were analyzed by immunohistochemistry, p=0.0001. (C) ANGPTL4 protein level was positively correlated with pAKT protein level. (D) The phosphorylation of AKT was analyzed with anti-phospho-AKT antibody and normalized with the levels of AKT in Western blotting. (E) AKT inhibitors abolished the promotion effect of ANGPTL4 on cell proliferation. (F) The gene signatures of AKT signaling (PID_PI3KCI_AKT_PATHWAY) were enriched with subgroup of ANGPTL4-Higher expression.