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Methylation analysis by direct bisulfite pyrosequencing in MDS patients before treatment. 2 genes were chosen for the validation. Mean methylation value for each CpG analyzed by direct bisulfite pyrosequencing in DNA from bone marrows. The mean methylation values for LGR6 and PMEPA1 in MDS patients B were listed and healthy donors N were added as a control. As shown in Figures (a) and (b), LGR6 (p value = 0.006) and PMEPA1 (p value = 0.008) were hypomethylated in MDS patients.
