FIGURE 4:

SVM analysis of known cancers offers promise in evaluating extent of disease. Maximum washin-slope and peak enhancement were associated with malignancy in SVM analysis of predictors of malignancy in ipsilateral and contralateral breast lesions. A 63-year-old woman had a new diagnosis of 8 mm right retroareolar papillary carcinoma with planned breast conservation. Breast MRI demonstrated two irregular masses and two additional foci (blue arrows) of abnormal enhancement (a, first postcontrast images). Manual volumes of interest annotating these foci on high temporal resolution MRI (b, high temporal resolution T₁-weighted subtraction images at 45 seconds postcontrast) demonstrated early peak enhancement (c). Subsequent MR-directed ultrasound and MRI biopsies yielded additional papillary carcinoma and papillary lesions, leading to surgical decision for mastectomy instead of breast conservation.