Table 1:
Taxa reported by microbiomic studies of external auditory canal and middle ear specimens
| EAC | Middle ear specimens | |||||
|---|---|---|---|---|---|---|
| Diagnosis | Controls, OME, AOM | OME/COMA | OME/rAOMB | AOM/rAOM/AOMwiPc | Chronic perforationsd | AOM-TT or PTTO |
| Number of studies | 3 | 5 | 1 | 3 | 3 | 2 |
| References | [4,6,64] | [2–4,7,18] | [21] | [6,61,62] | [9,11,20] | [5,17] |
| Bacteria | Alloiococcus (2) | Alcaligenaceae (1) | Alloiococcus (1) | Acinetobacter (1) | Alcaligenaceae (1) | Aerococcus (1) |
| Corynebacterium (2) | Alloiococcus (5) | Anaerococcus (1) | Actinobacteriaf (1) | Alloiococcus (2) | Campylobacter (1) | |
| Enterobacteria (1) | Caulobacteriume (1) | Brevibacterium (1) | Alloiococcus (2) | Anaerococcus (1) | Corynebacterium (2) | |
| Haemophilus (2) | Chitinophagaceae (1) | Clostridialesg (1) | Corynebacterium (2) | Bacteroides (1) | Delftia (1) | |
| Moraxella (1) | Corynebacterium (3) | Corynebacterium (1) | Haemophilus (3) | Brevibacterium (1) | Dolosigranulum (1) | |
| Pseudomonas (1) | Enterobacteria (3) | Dolosigranulum (1) | Moraxella (3) | Campylobacter (1) | Eikenella (1) | |
| Streptococcus (2) | Fusobacteriaf (1) | Finegoldia (1) | Lactococcus (1) | Corynebacterium (3) | Enterococcus (1) | |
| Staphylococcus (2) | Fusobacterium (1) | Haemophilus (1) | Prevotella (1) | Fusobacterium (1) | Haemophilus (1) | |
| Turicella (1) | Haemophilus (5) | Moraxella (1) | Pseudomonas (1) | Gordonia (1) | Klebsiella (1) | |
| Moraxella (4) | Parvimonas (1) | Sphingobacteriaf (1) | Haemophilus (2) | Marinobacter (1) | ||
| Neisseria (1) | Peptoniphilus (1) | Staphylococcus (3) | Klebsiella (1) | Moraxella (1) | ||
| Porphyromonas (1) | Porphyromonas (1) | Streptococcus (3) | Nevstta (1) | Parvimonas (1) | ||
| Streptococcus (4) | Pseudoclavibacter (1) | Turicella (3) | Ochrobactrum (1) | Peptoniphilus (1) | ||
| Pseudomonas (3) | Pseudomonas (1) | Veillonella (1) | Oligella (1) | Peptostreptococcus (1) | ||
| Staphylococcus (5) | Serratia (1) | Parvimonas (1) | Poryphyromonas (1) | |||
| Stenotrophomonas (1) | Staphylococcus (1) | Peptoniphilus (1) | Propionibacterium (1) | |||
| Turcibacter (1) | Streptococcus (1) | Pedomicrobium (1) | Pseudomonas (2) | |||
| Turicella (3) | Turicella (1) | Peptostreptoccus (1) | Serratia (1) | |||
| Porphyromonas (1) | Sporobacterium (1) | |||||
| Propionibacterium (1) | Staphylococcus (2) | |||||
| Proteus (1) | Streptococcus (2) | |||||
| Pseudomonas (2) | Turicella (1) | |||||
| Raoultella (1) | ||||||
| Shewanella (1) | ||||||
| Staphylococcus (3) | ||||||
| Streptococcus (1) | ||||||
| Turicella (1) | ||||||
| Fungi | Aspergillus (1) | Aspergillus (1) | Aspergillus (1) | |||
| Candida (1) | Candida (1) | |||||
| Malassezia (1) | ||||||
| Nakaseomyces (1) | ||||||
| Penicillium (1) | ||||||
| Saccharomyces (1) | ||||||
Data are limited to dominant taxa reported by each study. Unless otherwise indicated, dominant taxa are shown at the genus-level, consistent with nomenclature used in most microbiota studies. Bracketed numbers indicate the number of studies that reported each taxon. AOM: Acute otitis media. AOMwiP: Acute otitis media with spontaneous perforation of the tympanic membrane. AOM-TT: Acute otitis media associated with tympanostomy tubes with otorrhoea. COM: Chronic otitis media. EAC: External auditory canal. OME: Otitis media with effusion. rAOM: Recurrent acute otitis media. PTTO: Post-tympanostomy tube otorrhoea. References are numbered consistent with the main manuscript.
Krueger et al. [2] defined COM as the presence of middle ear fluid for >3-months.
Boers et al. [21] combined data from patients with OME or rAOM.
Sillanpää et al. [61] combined data from patients with AOM, AOM with spontaneous perforation of the tympanic membrane (AOMwiP) or AOM associated with tympanostomy tubes complicated by otorrhoea.
Includes data from patients with suppurative and dry chronic perforations.
Genus name as reported by Chan et al. [18].
Sequences not identified below the phylum-level.
Sequences not identified below the class-level