. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Int J Pediatr Otorhinolaryngol. 2019 Dec 18;130(Suppl 1):109836. doi: 10.1016/j.ijporl.2019.109836

Table 2.

Advances towards therapeutics that use commensal species to prevent infection from related bacterial pathogens

Disease	Target pathogen	Commensal Species	Development stage	Ref
Otitis media	Streptococcus pneumoniae	α-haemolytic Streptococci	Phase II -children	[162]
Pharyngitis	Streptococcus pyogenes	Streptococcus salivarius	Licensed product	[163]
Pneumonia	S. pneumoniae	Streptococcus mitis	Pre-clinical	[164]
Meningitis	Neisseria meningitidis	Neisseria lactamica	Pre-clinical	[165,166]
Bacteraemia	Staphylococcus aureus	Staphylococcus lugdunensis	Phase I -adults	[114]
Salmonellosis	Salmonella typhi(murium)	Escherichia coli	Pre-clinical	[167]