Mais 1995b.

Methods	Unit of randomisation: participant Method of randomisation: random numbers table ‐ numbered sealed envelopes Time of randomisation: at completion of surgery Blinding: double
Participants	Patients undergoing myomectomy by laparoscopy N = 50 Dropouts: nil Myomectomy consisted of removal of 1 to 4 myomas; largest was 3 to 6 cm Indication for surgery: fibroids; not specifically participants with infertility Pre‐existing adhesions: no Microsurgery: no Age, years, mean (SD): treatment group 34.1 (5.7); control group 33.2 (5.5) Location: Italy Timing and duration: January 1993 to June 1994
Interventions	Oxidised regenerated cellulose on myomectomy incision(s) vs uncovered myomectomy site(s) Other adjuvants used: none Second‐look laparoscopy Timing: 12 to 14 weeks after initial surgery Surgeon unaware: yes Adhesiolysis: not stated
Outcomes	Adhesions at second‐look laparoscopy 12 to 14 weeks later Incidence (per participant) Severity: graded as filmy and avascular, dense and/or vascular, or cohesive Adverse effects Pregnancy: not stated
Notes	Power calculations: nil Documentation: not stated No source of funding stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Treatment or control assignment was obtained by using a table of random digits
Allocation concealment (selection bias)	Low risk	Numbered, sealed envelopes were used to conceal allocation. The envelope seal was broken in the operation room after completion of all operative procedures and before removal of laparoscopic ports
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Does not state whether initial surgeon was blinded; however as control was no treatment, appears unlikely that they were. Not clearly stated whether participants were blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Independent blinded surgeons performed second‐look laparoscopy
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No mention of whether withdrawals or dropouts occurred during the study
Selective reporting (reporting bias)	Unclear risk	Data reported in incidences/percentages. No range or CI reported. P values reported only for significant results. No conversion of data or subsets
Other bias	Low risk	No other bias identified