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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Pain. 2020 Apr;161(4):842–855. doi: 10.1097/j.pain.0000000000001768

Figure 9. Effects of CYM51010 on mechanical and heat hypersensitivities in wild-type (WT) and μ-OR knockout (KO) mice after nerve injury.

Figure 9.

(A, B) Changes in ipsilateral (left panel) and contralateral (right panel) paw withdrawal frequencies to low force (0.07 g, A) and high force (0.4 g, B) mechanical stimuli after systemic administration of CYM51010 (2 mg/kg, s.c.) in WT and μ-OR KO mice with SNL. (C) Effects of CYM51010 (2 mg/kg) on the ipsilateral (left panel) and contralateral (right panel) paw withdrawal latency to heat stimulation in WT and μ-OR KO mice with SNL. n = 6–8/group. *p < 0.05, **p < 0.01, ***p < 0.001 versus WT; #p < 0.05, ###p < 0.001 versus pre-drug baseline. Two-way mixed model ANOVA. Data are mean ± SEM.